Over the past decades, advances in bioengineering and expanded insight in tumor immunology have resulted in the emergence of novel bispecific antibody (bsAb) constructs. Pre-clinical studies of various bsAb constructs have shown impressive results in terms of immune effector cell retargeting, target dependent activation and the induction of anti-tumor responses.
With advanced technology and years of experience, Creative Biolabs now is able to supply all kinds of bispecific antibodies and bispecific antibody production related service for scientific or clinical research use.
Bispecific antibody is an artificial protein that is composed of fragments of two different monoclonal antibodies and consequently binds to two different types of antigens. The most widely used application of this approach is in cancer immunotherapy.
BsAb are capable of bridging two different molecules. There are at least 30 different BsAbs and related molecules in clinical development currently, two of which have been approved to be put onto market, catumaxomab (REMOVAB®) and blinatumomab (BLINCYTO®), which also suggests that bsAbs can be developed as promising therapeutic agents.
According to the antibody structure, BsAbs and other bispecific immunotherapeutics that Creative Biolabs can provide are claasified into five major groups, bispcific IgGs, appended IgGs, BsAb fragments, bispecific fusion proteins and BsAb conjugates.
BsAbs have a wide application range. Creative Biolabs offers custom BsAb services according to specific research requirements. Their application domains include oncology, immunology, hematology, ophthalmology, osteology, pulmonary and respiratory diseases, pretargeting system, diagnostics, gene therapy, etc.
“With our novel strategies and proprietary Creative Discovery Platform™, we can adjust the format, valency, flexibility and half-life of BsAbs to meet every client`s requirements”, said Dr. Monica Müller, scientific officer of Creative Biolabs.
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early antibody drug discovery and development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world.