Creative Biolabs Released Native™ Antibody Discovery Service to Conquer the Shortcomings of In Vitro Antibody Display Methods

Press Release

Creative Biolabs is glad to release Native™ Antibody Discovery Service. It has developed the unique Native™ Antibody Discovery Platform to develop native monoclonal antibodies using antigen-specific B lymphocytes cytometry technology.

Current in vitro antibody display methods cannot provide antibodies with naturally paired heavy chain and light chain, such as phage display and ribosome display. Besides, antibodies derived from in vitro antibody display methods generally have moderate affinity to the targets, often in the range of 1–50 nM KD, so usually they require affinity maturation to be used as potential therapeutics.

To overcome these shortcomings of in vitro antibody display methods, Creative Biolabs developed Native™ Antibody Discovery Platform. This platform is able to isolate single antigen specific plasma cells to retrieve native antibodies with extremely high in vivo specificity and affinity. This new technology allows researchers to select a large number of antibody candidates at once. Moreover, the selection takes only 2-3 weeks post-immunization.

It is considered by now the most efficient native antibody service to develop native monoclonal antibodies from humans, rabbits, rats, mice, chicken and other species such as sheep, monkeys, dogs, camelids, and even cows.

“We provide native monoclonal antibodies for both academic and clinical use. Our highly professional scientists are confident in providing the domestic and international customers with best possible services while at the most competitive price,” said Dr. Monica Müller, scientific officer of Creative Biolabs.

As Ms Monica introduced, the features of their Native™ Antibody Discovery Service lie in native paired heavy chain and light chain, in vivo affinity maturation, high specificity and stability in vivo, diverse species such as human, mouse, rabbit, chicken, monkey, rat, dog, and alligator, large pool of antibody candidates and competitive and affordable price.

About Creative Biolabs

Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early antibody drug discovery and development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world.