5-Sulfosalicylic acid, an off-white to gray crystalline powder, is a strong acid. It is also known as 2-Hydroxybenzoic-5-sulfonic, 2-Hydroxy-5-sulfobenzoic acid, or 3-Carboxy-4-hydroxybenzenesulfonic Acid. This clear and colorless acid is capable of protonating water. 5- Sulfosalicylic acid has a molecular formula C7H6O6S. It bears the molecular weight of 254.2. It is soluble in ether, ethanol, alcohol, and water. The acid’s solutions need to be protected from heat, light as well as moisture. Therefore, it is often stored in well-closed containers. This product also requires protection from oxidizers.
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5-Sulfosalicylic acid acts as a reagent. It is adopted in urine tests to check for urine protein content. Its presence leads to precipitation of dissolved proteins in serum and tissue. This is gauged from the degree of turbidity. In gel electrophoresis, the charged molecules are bifurcated based on their physical properties like charge, mass, etc. This technique is often used to separate proteins. Using it, individual proteins in complex samples or multiple proteins within a single sample can be identified. It also assists in the detection of cobalt. It is often described as a tri-functional aromatic compound and is known to undergo reactions that are typical of carboxylic, phenols, and sulfonic acid groups.
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Industrial applications of 5- Sulfosalicylic acid encompass as a metal chelating agent, and in preparation of organic catalysts, surface-active agents, and grease additives. It can be used to detect metals in solutions and samples derived from the solid state. It is widely used in fixing solutions for IEF (Isoelectric Focusing), SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis), and PAGE.
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5-Sulfosalicylic acid is harmful if swallowed by humans. It enters the system through skin, eyes, nose or mouth and irritates the lungs and the respiratory tract. Therefore, industries have to follow engineering controls like exhaust ventilation to maintain recommended exposure limits.
Key vendors of 5-Sulfosalicylic acid in China are Xilong Chemical Co. Ltd., Fine Chemicals Group Co. Ltd., Shengchuang Fine Chemicals Co. Ltd., and Zhejiang Paula Industry Co. Ltd. Other participants in the global space include Bhagwati Chemicals ChemFine International Co. Ltd., Chemical Point UG, etc.
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